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This visualization depicts the dose response behavior of 158 compounds in 53 cancer models; the primary heatmap indicates the potency of the compound (EC₅₀ in μM) with color and efficacy (area under the curve, or AUC) with point size. Either or both of these visualized dimensions can be turned off with checkboxes at the lower left. Missing dots indicate drug-model combinations that were not tested. Two other plots, "Compound Summary" and "Cell Line Summary," depict the distribution of AUC values for all compounds and cell lines tested respectively. These plots include box and whisker plots, with combinations lying more than 1 inter-quartile range (IQR) above the third quartile or more than 1 IQR below the first quartile highlighted as outliers. Hovering over any dot in the heatmap or any outlier in the summary plots will display the compound and model it represents; clicking will display the chemical structure of the compound, the dose-response parameters of that compound in that model, and a plot of the measured dose-response values and the best fit curve. Curves plotted in red exhibit poor quality of fit (R² less than 0.5) or a suspect fit to high efficacy across all concentrations tested.

Those who wish to compare dose-response curves of different combinations may do so using an overlay plot (not visible by default). Clicking the "Add to Overlay" button below a dose-response plot will add that curve to the overlay plot, which can be viewed by clicking the "View Overlay" button. The overlay plot can be hidden again using the "X" icon at its upper right. Up to six dose response curves may be added to the overlay plot at one time

Filters on the left can be used to reduce the number of compounds or models depicted in the main plots. Compounds can be filtered by selecting a subset of mechanism classes, a subset of more specific targets, or including a string to match in the compounds name (e.g. "parib" matching the compounds "Olaparib" and "Talazoparib"). Models can be filtered by select a subset of tumor types, or including a string to match in the model's name. Note that all filters will be matched; a warning message will be displayed if no compounds or models are available that match the specified filters. Matching compounds and models will be displayed in the heatmap. In the compound summary plot, boxplots will be included only for matching compounds; points will be plotted for all models, but those matching the specified filters will be highlighted in red. The cell line summary plot will be affected similarly, with the effect of the compound and model filters reversed. To remove all filters, select "None" in all drop-down lists, and clear both search fields, and click "Update." The full heatmap will also be restored by reloading the page.

Click "OK" below to hide this help window. If the visualization is difficult to view, we recommend using your browser's zoom function (usually, Ctrl+) to zoom in or out on the visualization.